Chemical Signaling The primary means by which cell-to-cell communication, as well as homeostasis in multicellular organisms, occurs, involves protein receptors by receiving cells. Chemical signaling can involve small molecules (ligands) or large molecules (cell-surface signaling proteins). Read More: What is signaling in biology? Chemical signaling and orientation The chemicals used in the bee signaling and orientation system can be divided into two groups. The first includes those that are secreted by the bees themselves, the second - natural odorous substances that are part of food and propolis, as well as the secretions of enemies of bees. Both of them are used by bees to coordinate many behavioral acts, the understanding of which is impossible without an analysis of the role of chemical signals. Example: {In chemical signaling, a cell may target itself (autocrine signaling), a cell connected by gap junctions or plasmodesmata (direct signaling), a nearby cell (paracrine signaling), ...
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